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Study identifier: NCT06217198 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Computerized Depression Intervention in Veterans

Condition: Depression  ·  Sponsor: VA Office of Research and Development

PhaseNA
Planned participants152
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Depressive symptoms are common among Veterans and associated with significant impairment. Timely intervention has the potential to improve mental health outcomes and restore functioning. Interventions delivered through the internet can be completed remotely at any time, and thus minimize burden on Veterans, however the research examining their utility in Veterans is limited. This proposed project will examine Deprexis, a self-guided internet-delivered intervention, which targets depressive symptoms and associated functional impairments. Interviews will be conducted to gain insight into Veterans' perceptions, needs, and preferences vis-a-vis Deprexis, with results informing a randomized controlled trial. Here an 8-week course of Deprexis will be compared to a treatment-as-usual (TAU) control condition to establish if Deprexis is acceptable and effective for Veterans with mild to moderate depressive symptoms. Veterans engaged in Deprexis are hypothesized to show improvements on measures of functioning and decreases in depressive symptoms compared to the TAU control group. The proposed work has great clinical utility, as it could provide a readily accessible, high-quality intervention for the many Veterans suffering from depressive symptoms, with the potential to improve functioning and long-term outcomes.

This description comes directly from the study's public registry record.

Talk to the study team

Rahel R Pearson, PhD  ·  (254) 297-5155  ·  rahel.pearson@va.gov

Joseph F Maher  ·  (254) 743-1478  ·  Joseph.Maher@va.gov

Always discuss trial participation with your own doctor first.

Locations (1)

Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TXWaco, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06217198