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Study identifier: NCT06214065 Synced from ClinicalTrials.gov · July 29, 2026
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Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder (ASD) Using Transcranial Magnetic Stimulation (TMS)

Condition: Autism Spectrum Disorder  ·  Sponsor: Yale University

PhaseNA
Planned participants80
Who can joinAll sexes, 18 Years to 35 Years
Healthy volunteersYes

About this study

The goal of this observational study is to test the modulation effect of different transcranial magnetic stimulation (TMS) on the neural network supporting our ability to create mental representations of others (also known as mentalizing) in young adults with autism. The main question it aims to answers is can stimulation of the right temporoparietal junction can change brain activity related to mentalizing during social interaction in the stimulation area and other brain areas connected to it. Researchers will compare results to a group of individuals without autism to see if the patterns of neural activity change are similar between the groups. Participants will undergo assessment of their clinical traits and social skills and baseline MRI scan. They will attend three additional visits that include TMS session and functional MRI scans before and right after TMS.

This description comes directly from the study's public registry record.

Talk to the study team

Michal Assaf, MD  ·  860-545-7792  ·  michal.assaf@hhchealth.org

Vaughn R Steele, MD  ·  860-545-7855  ·  vaughn.steele@yale.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Olin Neuropsychiatry Research Center (ONRC)Hartford, Connecticut, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06214065