Condition: De Novo Hypoxemic Acute Respiratory Failure (hARF) · Sponsor: Assistance Publique - Hôpitaux de Paris
De novo hypoxemic acute respiratory failure (hARF) is one of the main causes of intensive care unit (ICU) admission. In de novo hARF, intubation is associated with a dramatic increase in mortality rate. Compared to standard oxygen, the use of high-flow oxygen nasal cannula (HFNC) might be beneficial to prevent intubation and mortality, although the results of trials and meta-analyses are conflicting. Even with HFNC, the intubation rate remains high. This is the reason why adjunctive therapies, administered in addition to HFNC are needed. Continuous positive airway pressure (CPAP) is one of these adjunctive therapies. CPAP provides high level of positive end-expiratory pressure that ensures lung recruitment, but without adding inspiratory pressure support, which prevents ventilator induced lung injury. In addition, as opposed to pressure support, CPAP is well tolerated during long periods of time. Therefore, applying CPAP in addition to HFNC may reduce intubation rate and in turn mortality rate. The present trial will evaluate the impact on mortality of a strategy including continuous positive airway pressure plus high flow nasal cannula oxygen therapy versus high flow nasal cannula oxygen therapy alone in patients with de novo acute hypoxemic respiratory failure: a Prospective, Randomized Controlled Trial
This description comes directly from the study's public registry record.
Alexandre DEMOULE · +33 (0)1 42 16 77 61 · alexandre.demoule@aphp.fr
Always discuss trial participation with your own doctor first.
| CHU Amiens-Picardie | Amiens, France | Not Yet Recruiting |
| CHU Angers | Angers, France | Not Yet Recruiting |
| Centre Hospitalier Victor Dupouy | Argenteuil, France | Not Yet Recruiting |
| Hôpital Avicenne | Bobigny, France | Not Yet Recruiting |
| Centre Hospitalier de Bourg-en-Bresse - Site de Fleyriat | Bourg-en-Bresse, France | Recruiting |
| Hôpital Louis-Mourier | Colombes, France | Not Yet Recruiting |
| Centre Hospitalier Sud Francilien | Corbeil-Essonnes, France | Not Yet Recruiting |
| Hôpital Henri-Mondor | Créteil, France | Recruiting |
| Centre Hospitalier de Dieppe - Site Pasteur | Dieppe, France | Recruiting |
| Hôpital François Mitterrand | Dijon, France | Recruiting |
| Hôpital André Mignot | Le Chesnay, France | Recruiting |
| Hôpital Bicêtre | Le Kremlin-Bicêtre, France | Not Yet Recruiting |
+ 17 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06213168