Condition: Kidney Transplantation · Multiparametric Magnetic Resonance Imaging · Living Donors · Sponsor: Patrick Schjelderup
Development of renal fibrosis is the irreversible culmination of various renal diseases and independently predicts adverse outcomes. Currently renal fibrosis can only be diagnosed by performing a renal biopsy. The procedure is invasive and is limited by sampling bias. In recent years there has been a significant development in magnetic resonance imaging (MRI) based techniques. MRI can provide highly detailed anatomical images. Other MRI measures allow quantitative measurements of perfusion, oxygenation, tissue stiffness and diffusion of water molecules within tissue. The combination of several MRI techniques sensitive to different biophysical tissue properties in a single scan session is referred to as multiparametric MRI (mpMRI). Emerging evidence suggests that mpMRI could represent a method for indirect characterization of renal microstructure and extent of fibrosis. So far, studies performed in living kidney donors and recipients have been mostly cross-sectional. For mpMRI to transition to the clinical setting there is a need for validation of MRI-based measures with currently used reference methods for quantifying renal function and fibrosis. The aim of this longitudinal observational study in a cohort of living kidney donors, recipients and healthy controls is to investigate the utility of repeated mpMRI over a period of 2 years. MRI-based measures will be compared to current reference methods for quantifying renal function and fibrosis. The investigators hypothesize…
This description comes directly from the study's public registry record.
Patrick Schjelderup, MD · +4597666015 · pasc@rn.dk
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| Department of Renal Medicine, Aarhus University Hospital | Aarhus, Central Jutland, Denmark | Recruiting |
| Department of Nephrology, Aalborg University Hospital | Aalborg, North Denmark, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06210555