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Study identifier: NCT06209099 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Organ Preservation First Strategy and Intentional Watch and Wait for MRI Defined Low-risk Rectal Cancer

Condition: Rectal Cancer  ·  Sponsor: Peking University Cancer Hospital & Institute

PhaseNA
Planned participants96
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to test the safety and efficacy of local excision (LE) or non-operative management (NOM) in patients with MRI defined low-risk rectal cancer following neoadjuvant intensity modulated radiotherapy with concurrent capecitabine plus consolidation CapeOX. The main questions it aims to answer are: 1. What is the organ-preservation rate (OPR) after in patients with MRI defined low-risk rectal cancer following neoadjuvant intensity modulated radiotherapy with concurrent capecitabine plus consolidation CapeOX? 2. Is LE or NOM safe and effective in patients with MRI defined low-risk rectal cancer following neoadjuvant intensity modulated radiotherapy with concurrent capecitabine plus consolidation CapeOX? Participants will receive radical surgery, LE, or NOM based on the response of neoadjuvant intensity modulated radiotherapy with concurrent capecitabine plus consolidation CapeOX in patients with MRI defined low-risk rectal cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Xiaokang Lei, M.D.  ·  +8610-88196086  ·  lxkpku@163.com

Lin Wang, M.D.  ·  +8613910975011  ·  wanglinmd@foxmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Peking University Cancer Hospital & InstituteBeijing, Haidian District, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06209099