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Study identifier: NCT06205316 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma

Condition: Biochemically Recurrent Prostate Carcinoma · Oligometastatic Prostate Carcinoma · Recurrent Prostate Adenocarcinoma  ·  Sponsor: Mayo Clinic

PhasePhase 3
Planned participants118
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase III trial tests the side effects of stereotactic body radiation therapy (SBRT) compared to hypofractionated radiotherapy for treating patients with prostate adenocarcinoma that has come back after a period of improvement (recurrent) or that has spread from where it first started (primary site) to a limited number of sites (oligometastatic). SBRT is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body (except the brain). The total dose of radiation is divided into smaller doses given over several days. This type of radiation therapy helps spare normal tissue. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumors cells and have fewer side effects. SBRT may work just as well as hypofractionated radiation therapy at treating patients with biochemically recurrent or oligometastatic prostate cancer, but with a shorter treatment time and possibly fewer side effects.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Referral Office  ·  855-776-0015  ·  mayocliniccancerstudies@mayo.edu

Always discuss trial participation with your own doctor first.

Locations (6)

Mayo Clinic in ArizonaScottsdale, Arizona, United StatesRecruiting
Mayo Clinic Health System in Albert LeaAlbert Lea, Minnesota, United StatesNot Yet Recruiting
Mayo Clinic Health System - MankatoMankato, Minnesota, United StatesNot Yet Recruiting
Mayo Clinic in RochesterRochester, Minnesota, United StatesNot Yet Recruiting
Mayo Clinic Health System-Eau Claire ClinicEau Claire, Wisconsin, United StatesNot Yet Recruiting
Mayo Clinic Health System-Franciscan HealthcareLa Crosse, Wisconsin, United StatesNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06205316