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Study identifier: NCT06205056 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Evaluation of Safety and Immunogenicity of Ad26.Mos4.HIV and CH505 TF chTrimer Combination in Healthy Adults

Condition: Human Immunodeficiency Virus  ·  Sponsor: U.S. Army Medical Research and Development Command

PhasePhase 1
Planned participants78
Who can joinAll sexes, 18 Years to 50 Years
Healthy volunteersYes

About this study

This is a Phase I, randomized, double-blind, placebo-controlled clinical study to define the safety and immunogenicity resulting from a rapid dose-escalating vaccination schedule as compared to that of a co-administered, dose-consistent vaccination schedule. Participants randomized to receive vaccines will get either dose-consistent injections of CH505 TF chTrimer+ALFQ co-administered with Ad26.Mos4.HIV or rapid, dose-escalating injections of CH505 TF chTrimer+ALFQ with an Ad26.Mos4.HIV prime, followed by dose-consistent injection of CH505 TF chTrimer+ALFQ co-administered with Ad26.Mos4.HIV

This description comes directly from the study's public registry record.

Talk to the study team

Grace Mirembe, MBChB, MMed  ·  +256 312 330400  ·  gmirembe@muwrp.org

Hannah Kibuuka, MBChB, MMed, MPH  ·  +256 312 330400  ·  hkibuuka@muwrp.org

Always discuss trial participation with your own doctor first.

Locations (1)

Makerere University Walter Reed Project (MUWRP)Kampala, UgandaRecruiting

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Source record: clinicaltrials.gov/study/NCT06205056