Condition: Metastatic Colorectal Cancer · Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
In mCRC, response to second-line chemotherapy is limited, and few treatment options are available. It is urgent to design an optimal second-line treatment regimen to improve the response rate and prolong the survival of patients with mCRC. Several studies preliminarily demonstrated that irinotecan, TAS-102 plus bevacizumab regimen could bring promising efficacy with a tolerable safety profile for patients with mCRC as a second-line treatment. This phase I/II study was aimed to determine the recommended phase II dose (RP2D) of the combination of TAS-102, irinotecan, and bevacizumab for future clinical trials in patients with mCRC refractory to both fluoropyrimidine and oxaliplatin and to evaluate its safety and preliminary efficacy.
This description comes directly from the study's public registry record.
Yongkun Sun · +8613141276041 · hsunyk@126.com
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| Cancer Hospital, Chinese Academy of Medical Sciences | Beijing, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06202001