Condition: Local Recurrence of Malignant Tumor of Prostate · Radiotherapy · Sponsor: Maria Sklodowska-Curie National Research Institute of Oncology
The goal of this clinical study is to evaluate the toxicity and efficacy of re-irradiation using focal stereotactic body radiotherapy (SBRT) in patients with local recurrence of prostate cancer after definitive or post-operative radiotherapy. The main question is the tolerance of such treatment, concerning the incidence of Grade ≥ 2 and Grade ≥ 3 GU and GI toxicity. Also the efficacy of SBRT will be measured in terms of Biochemical Control with other secondary endpoints which include: Biochemical Response, Biochemical Failure-Free Survival, Metastases-Free Survival, Relapse-Free Survial, Local Control, Overall Survival and patients' reported tolerance measured with Quality of Life questionnaires (QoL C-30 and PR-25). The evaluation of the tolerance and effectiveness of stereotactic radiotherapy (SBRT) will be performed in 3 subgroups: in patients with local recurrence after conventionally fractionated/moderately hypofractionated definitive radiotherapy (Group A) or ultrahypofractionated definitive SBRT (Group C) or after prostatectomy and post-operative radiotherapy (Group B). The study group is planned to include 55 patients.
This description comes directly from the study's public registry record.
Wojciech Majewski, MD, PhD · +48322788001 · wojciech.majewski@gliwice.nio.gov.pl
Aleksandra Napieralska, MD, PhD · +48322788001 · aleksandra.napieralska@gliwice.nio.gov.pl
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| Maria Sklodowska Memorial Research Institute of Oncology | Gliwice, Poland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06201078