Condition: Atrial Fibrillation Recurrent · Sponsor: University Medical Center Groningen
Various methods exist for performing pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF), including thermal ablation and pulse-field ablation (PFA). However, in cases requiring a second PVI for recurrent AF, radiofrequency ablation (RFA) is utilized in nearly 95% of instances post-acquiring a 3D high-density map from the left atrium (LA). Up to 85% of patients experiencing recurrent AF after the initial PVI exhibit pulmonary vein (PV) reconnections, often identified as the cause of AF. PFA has demonstrated its safety and efficiency compared to RFA as a swift technique for performing ablation. Yet, whether PFA or RFA stands out as superior or safer when applied for a second PVI remains unclear, as no randomized controlled trial has investigated this comparison. The proposed REPEAT-AF trial aims to randomize 154 AF patients experiencing recurrent AF after the initial PVI, assigning them in a 1:1 ratio to either RFA or PFA. Each patient will receive an implantable cardiac monitor to precisely detect any AF recurrences.
This description comes directly from the study's public registry record.
Yuri Blaauw, Dr. · +31503616161 · y.blaauw01@umcg.nl
Nick van Vreeswijk, drs. · +31503616161 · n.l.van.vreeswijk@umcg.nl
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| UMCG | Groningen, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06199180