Condition: Venous Thromboembolism · Deep Vein Thrombosis · Pulmonary Embolism · Sponsor: University Hospital, Angers
Lower limb trauma requiring immobilization is a very frequent condition that is associated with an increased risk of developing venous thromboembolism (VTE). The TRiP(cast) score has been developed to provide individual VTE risk stratification and help in thromboprophylactic anticoagulation decision. The recent CASTING study had confirmed that patients with a TRiP(cast) score \<7 have a very low risk of VTE and could be safely manage without prophylactic treatment. Conversely, patients with a score ≥ 7 have a high-risk of VTE and require a prophylactic anticoagulant treatment. Low molecular weight heparins (LMWH) have been shown to be effective in this indication. However, in the CASTING study, the 3-month symptomatic VTE rate was 2.6% in this subgroup despite LMWH prophylactic treatment. This result suggests that LMWH are not sufficiently effective in this particular subgroup of high-risk patients. Direct oral anticoagulants, and in particular rivaroxaban, may be an effective and safe alternative to LMWH. In the PRONOMOS study, comparing LMWH with rivaroxaban in patients who had undergone non-major lower limb surgery, the relative risk of symptomatic VTE was 0.25 (95% CI = 0.09 - 0.75) in favor of rivaroxaban 10mg. No significant increase in bleeding was found. In addition, as LMWH treatment requires subcutaneous daily injections, the use of rivaroxaban may positively impact patients' quality of life as well as being effective in medico-economic terms. The aims of this stud…
This description comes directly from the study's public registry record.
Delphine Douillet, Doctor · 0241353637 · Delphine.Douillet@chu-angers.fr
Cindy Augereau, Mrs · 0241354143 · Cindy.Augereau@chu-angers.fr
Always discuss trial participation with your own doctor first.
| Agen-Nerac Hospital, Emergency Department | Agen, France | Active Not Recruiting |
| Angers University Hospital, Emergency department | Angers, France | Recruiting |
| Argenteuil hospital, Emergency department | Argenteuil, France | Recruiting |
| Arpajon Hospital, Emergency Department | Arpajon, France | Withdrawn |
| Caen University hospital, Emergency department | Caen, France | Withdrawn |
| Tours University Hospital, Emergency department | Chambray-lès-Tours, France | Withdrawn |
| Cholet Hospital, Emergency department | Cholet, France | Recruiting |
| Clermont-Ferrand University Hospital, Emergency department | Clermont-Ferrand, France | Recruiting |
| Simone Veil Hospital, Emergency Department | Eaubonne, France | Recruiting |
| Eure-Seine Hospital, Emergency Departement | Évreux, France | Active Not Recruiting |
| Grenoble University Hospital, Emergency Department | Grenoble, France | Recruiting |
| La Roche sur Yon Hospital | La Roche-sur-Yon, France | Not Yet Recruiting |
+ 25 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06195540