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Study identifier: NCT06192615 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)

Condition: Delirium  ·  Sponsor: Massachusetts General Hospital

PhasePhase 3
Planned participants1800
Who can joinAll sexes, 60 Years to no upper limit
Healthy volunteersNo

About this study

This is a pragmatic phase III, randomized, blinded, double placebo-controlled, three-arm trial of elderly patients following cardiac surgery to assess the relationship between nighttime intravenous (IV) and sublingual dexmedetomidine on postoperative delirium and functional outcomes after surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Oluwaseun Johnson-Akeju, MD  ·  617-726-3030  ·  ojohnsonakeju@partners.org

Ariel Mueller, MA  ·  6177269252  ·  almueller@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (14)

Cedars-Sinai Medical CenterLos Angeles, California, United StatesNot Yet Recruiting
University of California San FranciscoSan Francisco, California, United StatesNot Yet Recruiting
Northwestern University Feinberg School of MedicineChicago, Illinois, United StatesRecruiting
University of Iowa Carver College of MedicineIowa City, Iowa, United StatesRecruiting
University of Maryland School of MedicineBaltimore, Maryland, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Washington University School of MedicineSt Louis, Missouri, United StatesNot Yet Recruiting
University of Nebraska Medical CenterOmaha, Nebraska, United StatesRecruiting
Columbia University Medical CenterNew York, New York, United StatesRecruiting
Montefiore Medical CenterThe Bronx, New York, United StatesNot Yet Recruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06192615