Condition: Schizophrenia and Related Disorders · Mitochondrial Alteration · Cognitive Impairment · Sponsor: Mclean Hospital
The goal of this double-blind, placebo-controlled randomized clinical trial is to test the effect of 12 weeks of orally administered MitoQ (mitoquinol mesylate) supplementation on cognition in 50 people with early phase schizophrenia-spectrum disorders (E-SSD) who have mitochondrial dysfunction (called high risk, or HR). Cognitive impairments in SSD can cause significant disability. Yet, there are no effective treatments for cognitive impairments in SSD. It has been shown that alterations in a certain type of brain cell (parvalbumin interneurons, or PVI) underlie cognitive deficits in SSD. These PVI, which fire at a fast rate, utilize high amounts of energy from the mitochondria and are highly vulnerable to oxidative stress. MitoQ is an antioxidant. Research has shown that, in mice, MitoQ can reduce oxidative stress in the mitochondria. The main question that this clinical trial aims to answer is: • Does MitoQ supplementation, compared to placebo, improve cognition in HR patients? Secondary questions that this clinical trial aims to answer are the following: Does MitoQ supplementation, compared to placebo: * Improve positive and negative symptoms of SSD in HR patients? * Improve functioning in HR patients? * Improve/normalize blood markers of mitochondrial dysfunction in HR patients? The investigators will enroll 100 individuals with E-SSD. These enrolled participants will participate in an initial screening visit to determine if they qualify for the actual clinical trial…
This description comes directly from the study's public registry record.
Dost Ongur, MD, PhD · 6178553922 · dongur@mgb.org
Steve Prete, RN · 6178552273 · sprete@mgb.org
Always discuss trial participation with your own doctor first.
| Yale School of Medicine | New Haven, Connecticut, United States | Not Yet Recruiting |
| McLean Hospital | Belmont, Massachusetts, United States | Recruiting |
| University of Lausanne | Lausanne, Switzerland | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06191965