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Study identifier: NCT06185556 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases

Condition: Colorectal Cancer · Liver Metastases · Liver Metastasis Colon Cancer  ·  Sponsor: Amsterdam UMC, location VUmc

PhasePhase 2/Phase 3
Planned participants78
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of this phase IIb/III, prospective, randomized clinical trial is to compare the efficacy of irreversible electroporation (IRE) with stereotactic body radiotherapy (SBRT) in patients with perivascular or peribiliary colorectal liver metastases (CRLM), that are not amenable for surgical resection or thermal ablation. Efficacy is assessed in terms of local control at 2 years.

This description comes directly from the study's public registry record.

Talk to the study team

Danielle J. Vos, M.D.  ·  +3120-4444571  ·  interventieradiologie@vumc.nl

Always discuss trial participation with your own doctor first.

Locations (1)

Amsterdam UMC - location VUmcAmsterdam, North Holland, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT06185556