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Study identifier: NCT06182397 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease

Condition: Arterial Disease of Legs · Below-the-knee Obstruction · PAD - Peripheral Arterial Disease  ·  Sponsor: Concept Medical Inc.

PhaseNA
Planned participants368
Who can joinAll sexes, 21 Years to no upper limit
Healthy volunteersNo

About this study

This is a Pivotal, Prospective, randomized, two arm, placebo controlled, single-blind, multicenter trial that will be conducted at approximately 80 sites; approx. 50 sites with at least 50% of subjects will be recruited from USA and approx. 30 sites OUS - Europe, Australia and Asia. Each site will be capped at 30 maximum subjects recruited. The main goal of this clinical trial is to determine the effectiveness and safety of the sirolimus drug coated balloon (DCB) versus standard percutaneous transluminal angioplasty (PTA) for the treatment of below the knee arterial disease. Eligible subjects will be randomised in a 1:1 allocation ratio and stratified by recruiting countries. Each subject will be randomized to receive either: 1. MagicTouch PTA sirolimus coated balloon catheter (DCB) in addition to standard balloon angioplasty or 2. Placebo balloon angioplasty in addition to standard balloon angioplasty (PTA).

This description comes directly from the study's public registry record.

Talk to the study team

Farhana Siddique  ·  +919725495366  ·  farhana@conceptmedical.com

Dario Gattuso  ·  +393292467132  ·  dario@conceptmedical.com

Always discuss trial participation with your own doctor first.

Locations (29)

Honor Health Research & Innovation InstituteScottsdale, Arizona, United StatesRecruiting
Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
University of California Los AngelesLos Angeles, California, United StatesNot Yet Recruiting
Clearwater Cardiovascular ConsultantsClearwater, Florida, United StatesRecruiting
Baptist Hospital of MiamiMiami, Florida, United StatesRecruiting
University of South FloridaTampa, Florida, United StatesRecruiting
Vascular Institute of the MidwestDavenport, Iowa, United StatesRecruiting
Unity Point Health Des MoinesDes Moines, Iowa, United StatesRecruiting
Atria Vascular and VeinFarmington Hills, Michigan, United StatesNot Yet Recruiting
Deborah Heart and Lung CenterBrowns Mills, New Jersey, United StatesRecruiting
Virtua Healthcare - Virtua Our Lady of LourdesMarlton, New Jersey, United StatesRecruiting
Northwell Health Long Island Jewish Medical CenterLake Success, New York, United StatesRecruiting

+ 17 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06182397