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Study identifier: NCT06180434 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Short Term Outcomes After PRoton and PhotoN RadiOtherapy for IDH Mutated Grade 2 and 3 Gliomas

Condition: Glioma · Radiotherapy; Complications  ·  Sponsor: Erasmus Medical Center

PhaseN/A
Planned participants320
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Rationale: Proton beam therapy has recently become available for the treatment of patients with WHO grade 2 and 3 IDH mutated (IDHmt) glioma in the Netherlands. The dose distributions associated with proton therapy have substantially reduced the volume of the normal brain irradiated with low and intermediate radiotherapy doses. Whether this impacts rates of progressive disease or safety issues and how this compares with a similar population treated with photon therapy is currently unknown. Objective: To investigate short term outcomes after proton and photon radiotherapy for grade 2 and 3 IDHmt glioma.

This description comes directly from the study's public registry record.

Talk to the study team

Steven HJ Nagtegaal, MD PhD  ·  +31(0)107042249  ·  s.nagtegaal@erasmusmc.nl

Alejandra Mendez Romero, MD PhD  ·  +31(0)107035829  ·  a.mendezromero@erasmusmc.nl

Always discuss trial participation with your own doctor first.

Locations (1)

Erasmus MCRotterdam, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT06180434