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Study identifier: NCT06180356 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Niraparib Rechallenge After Surgery in Ovarian Cancer Patients With Oligometastatic Progression

Condition: Ovarian Cancer · Oligometastatic Disease · Serous Ovarian Tumor  ·  Sponsor: MedSIR

PhasePhase 2
Planned participants30
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The ANALLISA study is a fast, proof-of-concept, phase II clinical trial which aims to assess the efficacy of niraparib rechallenge treatment after secondary cytoreductive surgery in ovarian cancer (OC) patients with oligometastatic progression (OMP) after first maintenance therapy with any PARP inhibitor. A total of 30 patients with OC and OMP will be enrolled and will receive treatment with niraparib 300 or 200 mg, according to body weight or platelet count. Patients will start treatment within 8 weeks after surgery and will receive it until progressive disease or treatment discontinuation. The main purpose of the study is to evaluate progression-free survival (PFS) of niraparib rechallenge in OC patients with OMP and no residual disease after secondary cytoreductive surgery.

This description comes directly from the study's public registry record.

Talk to the study team

MEDSIR  ·  + 34 932 214 135  ·  contact.trials@medsir.org

Always discuss trial participation with your own doctor first.

Locations (14)

Complejo Hospitalario Universitario A Coruña (CHUAC)A Coruña, SpainRecruiting
Hospital de CrucesBarakaldo, SpainRecruiting
Hospital Universitari Vall D'HebronBarcelona, SpainRecruiting
Institut Català d' Oncologia Girona (ICO)Girona, SpainRecruiting
Complejo Hospitalario de JaénJaén, SpainRecruiting
Hospital Universitario 12 de OctubreMadrid, SpainRecruiting
Hospital Universitario La PazMadrid, SpainRecruiting
Hospital Universitario Ramón y CajalMadrid, SpainRecruiting
Hospital Universitario Virgen de la VictoriaMálaga, SpainRecruiting
Hospital Universitario Central de Asturias (HUCA)Oviedo, SpainRecruiting
Hospital Universitario Virgen MacarenaSeville, SpainRecruiting
Hospital Universitari Sant Joan de ReusTarragona, SpainRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06180356