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Study identifier: NCT06175104 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

HeartGPS: A Study Exploring the Effects of a Psychological Intervention for Parents and Their Babies After Prenatal Cardiac Diagnosis

Condition: Heart Defects, Congenital · Anxiety in Pregnancy · Depression, Postpartum  ·  Sponsor: Children's Hospital Medical Center, Cincinnati

PhaseNA
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Babies with single ventricle congenital heart disease (SVCHD) are often diagnosed during pregnancy. While prenatal diagnosis has important clinical benefits, it is often stressful and overwhelming for parents, and many express a need for psychological support. HeartGPS is a psychological intervention for parents who receive their baby's diagnosis of SVCHD during pregnancy. It includes 8 sessions with a psychologist, coupled with tailored educational resources, and a personalized care plan. The intervention focuses on fostering parent psychological adjustment and wellbeing, and supporting parents to bond with their baby in ways that feel right for them. Through this study, the investigators will learn if HeartGPS is useful and effective for parents and their babies when it is offered in addition to usual fetal cardiac care. The investigators will examine the effects of the HeartGPS intervention on parental anxiety, depression, and traumatic stress; fetal and infant brain development; parent-infant bonding; and infant neurobehavioral and neurodevelopmental outcomes. The investigators will also explore mechanisms associated with stress biology during pregnancy, infant brain development and neurodevelopmental outcomes, and parent and infant intervention effects.

This description comes directly from the study's public registry record.

Talk to the study team

Nadine A. Kasparian, PhD  ·  513-636-5575  ·  nadine.kasparian@cchmc.org

James F. Cnota, MD  ·  513-636-3868  ·  james.cnota@cchmc.org

Always discuss trial participation with your own doctor first.

Locations (4)

Children's Hospital Los AngelesLos Angeles, California, United StatesNot Yet Recruiting
Children's Hospital Medical Center, CincinnatiCincinnati, Ohio, United StatesRecruiting
Sydney Children's HospitalRandwick, New South Wales, AustraliaNot Yet Recruiting
The Children's Hospital at WestmeadWestmead, New South Wales, AustraliaNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06175104