← Eichor
Study identifier: NCT06174116 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Metabolic Effects of Adjunctive Lumateperone Treatment in Clozapine-Treated Patients With Schizophrenia

Condition: Schizophrenia · Schizo Affective Disorder  ·  Sponsor: University of Massachusetts, Worcester

PhasePhase 4
Planned participants50
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The main question this study is trying to answer is whether lumateperone, an FDA-approved antipsychotic drug, can help reduce possible side effects of clozapine, such as weight gain and elevated levels of sugar and bad cholesterol. Participants will be randomly assigned to either take lumateperone (Caplyta) or a placebo for 12 weeks, in addition to their regularly prescribed clozapine. During their participation, patients will answer questions about their psychiatric and daily functioning, have blood drawn, and have their body composition analyzed (similar to stepping on a scale).

This description comes directly from the study's public registry record.

Talk to the study team

Abaigeal Grant, BA  ·  5088563027  ·  abaigeal.grant2@umassmed.edu

Always discuss trial participation with your own doctor first.

Locations (1)

UMass Chan Medical SchoolWorcester, Massachusetts, United StatesRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT06174116