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Study identifier: NCT06172010 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection

Condition: Prosthetic-joint Infection · Infection Hip · Infection; Knee, Joint  ·  Sponsor: Leiden University Medical Center

PhasePhase 4
Planned participants316
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

In this Dutch multicenter clinical trial, patients with a staphylococcal prosthetic joint infection, will, in the oral antibiotic treatment phase, be randomized between clindamycin monotherapy and rifampicin / levofloxacin combination therapy. The clinical endpoint will be treatment success one year after finishing antimicrobial treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Henk Scheper, MD  ·  071-5299239  ·  h.scheper@lumc.nl

Mark De Boer, MD PhD  ·  071-5269111  ·  M.G.J.de_Boer@lumc.nl

Always discuss trial participation with your own doctor first.

Locations (13)

LUMCLeiden, Zuid Hollans, NetherlandsRecruiting
Amsterdam UMCAmsterdam, NetherlandsRecruiting
OLVGAmsterdam, NetherlandsRecruiting
Martini ziekenhuisGroningen, NetherlandsNot Yet Recruiting
UMCGGroningen, NetherlandsRecruiting
Spaarne gasthuisHoofddorp, NetherlandsRecruiting
Medisch Centrum LeeuwardenLeeuwarden, NetherlandsRecruiting
Alrijne ZiekenhuisLeiderdorp, NetherlandsRecruiting
Radboud UMCNijmegen, NetherlandsRecruiting
Sint maartenskliniekNijmegen, NetherlandsRecruiting
Erasmus MCRotterdam, NetherlandsNot Yet Recruiting
Elisabeth Tweesteden ZiekenhusTilburg, NetherlandsRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06172010