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Study identifier: NCT06171750 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

Condition: Advanced Solid Tumor · Cutaneous Tumor · Subcutaneous Tumor  ·  Sponsor: Ankyra Therapeutics, Inc

PhasePhase 1
Planned participants97
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase 1, multicenter, open-label dose escalation study to determine the safety and tolerability of intratumoral (IT) injection of tolododekin alfa (ANK-101) in participants with advanced solid tumors who have progressed during or after receiving standard of care (SOC) therapy or who will not benefit from such therapy. The study will be conducted in three parts; in Part 1, participants with superficial lesions will receive ANK-101 as a single agent; in Part 2, participants with visceral lesions will receive ANK-101 as a single agent; and in Part 3, participants with cutaneous squamous cell carcinoma (CSCC) will receive ANK-101 in combination with cemiplimab.

This description comes directly from the study's public registry record.

Talk to the study team

Gail Iodice, BSN, RN  ·  347-882-1147  ·  giodice@ankyratx.com

Always discuss trial participation with your own doctor first.

Locations (5)

National Cancer InstituteBethesda, Maryland, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Providence Cancer InstitutePortland, Oregon, United StatesRecruiting
Hillman Cancer CenterPittsburgh, Pennsylvania, United StatesRecruiting
Princess Margaret Cancer CentreToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06171750