Condition: Multiple Sclerosis · Multiple Sclerosis Fatigue · Sponsor: Johns Hopkins University
Fatigue is a prevalent and disabling symptom in Multiple Sclerosis (MS), affecting up to 90% of patients. Current treatments, including off-label prescriptions of wake-promoting agents, have shown limited effectiveness. Previous research indicates that these agents may be beneficial specifically for MS patients with concomitant excessive daytime sleepiness. This study uses a randomized, double-blind, placebo-controlled crossover design. Participants will undergo a 10-day lead-in with he medication/placebo, followed by two four-week treatment periods separated by a one-week washout. Outcomes will be measured primarily using the Modified Fatigue Impact Scale (MFIS), with additional exploratory measures collected via a smartphone app that assesses fatigue through keystroke dynamics. This novel approach to fatigue measurement aims to capture real-time variations and provide more granular data than traditional self-report questionnaires.
This description comes directly from the study's public registry record.
Lauren Vega, BSN · 410-614-1522 · Ldimarc2@jhmi.edu
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| Johns Hopkins University | Baltimore, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06170970