Condition: Alpha1-Antitrypsin Deficiency · Sponsor: Takeda
The liver produces a protein called alpha-1 antitrypsin (AAT). AAT is normally released into the bloodstream. In some people, the liver makes an abnormal version of the AAT protein, called Z-AAT. Making an abnormal version of the AAT protein can result in liver disease as Z-AAT builds up in liver cells, which leads to liver problems such as liver scarring (fibrosis), continuing liver damage (cirrhosis), and eventually end stage liver disease. Fazirsiran is a medicine that reduces the creation of the Z-AAT protein and thus the build-up of this abnormal protein in the liver. People with this type of liver disease who already have mild liver scarring will take part in the study. They will be treated with fazirsiran or a placebo for about 2 years. This study will check the long-term safety of fazirsiran, whether participants tolerate the treatment and if there are any effects on liver scarring. A liver biopsy, a way of collecting a small tissue sample from the liver, will be taken twice during the study.
This description comes directly from the study's public registry record.
Takeda Contact · +1-877-825-3327 · medinfoUS@takeda.com
Always discuss trial participation with your own doctor first.
| St Joseph's Hospital and Medical Center | Phoenix, Arizona, United States | Recruiting |
| Mayo Clinic - PPDS | Phoenix, Arizona, United States | Recruiting |
| University of Arizona Thomas D. Boyer Liver Institute | Tucson, Arizona, United States | Recruiting |
| University of California San Diego | La Jolla, California, United States | Recruiting |
| UCLA Pulmonary and Critical Care | Los Angeles, California, United States | Recruiting |
| University of California Benioff Children's Hospital | San Francisco, California, United States | Recruiting |
| Peak Gastroenterology Associates | Colorado Springs, Colorado, United States | Recruiting |
| Schiff Center for Liver Diseases/University of Miami | Miami, Florida, United States | Recruiting |
| Indiana University School of Medicine-Indianapolis | Indianapolis, Indiana, United States | Recruiting |
| University Of Iowa Hospitals And Clinics | Iowa City, Iowa, United States | Recruiting |
| Boston Medical Center | Boston, Massachusetts, United States | Recruiting |
| University of Michigan Hospital - 1500 E Medical Center Dr | Ann Arbor, Michigan, United States | Recruiting |
+ 29 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06165341