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Study identifier: NCT06160752 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations

Condition: Locally Advanced Cholangiocarcinoma · Intrahepatic Cholangiocarcinoma · Solid Tumor  ·  Sponsor: Tyra Biosciences, Inc

PhasePhase 1
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of TYRA-200 in cancers with FGFR2 activating gene alterations, including unresectable locally advanced/metastatic intrahepatic cholangiocarcinoma and other advanced solid tumors.

This description comes directly from the study's public registry record.

Talk to the study team

Grace Indyk  ·  (619)728-4805  ·  TyraClinicalTrials@tyra.bio

Always discuss trial participation with your own doctor first.

Locations (4)

University of California San Francisco (UCSF)San Francisco, California, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
The Ohio State UniversityColumbus, Ohio, United StatesRecruiting
The University of Texas MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06160752