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Study identifier: NCT06158139 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Autologous CAR-T Cells Targeting B7-H3 in PDAC

Condition: Pancreas Cancer · Relapse · Resistant Cancer  ·  Sponsor: UNC Lineberger Comprehensive Cancer Center

PhasePhase 1
Planned participants27
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this gene therapy research study is to test the safety and tolerability of using a new treatment called autologous T lymphocyte chimeric antigen receptor cells against the B7-H3 antigen (iC9.CAR.B7-H3 T cells) in patients with pancreatic ductal adenocarcinoma that came back after receiving standard therapy for this cancer. The iC9.CAR.B7-H3 treatment is experimental and has not been approved by the Food and Drug Administration.

This description comes directly from the study's public registry record.

Talk to the study team

Catherine Cheng  ·  +1 919-445-4208  ·  UNCImmunotherapy@med.unc.edu

Caroline Babinec  ·  UNCImmunotherapy@med.unc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer CenterChapel Hill, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06158139