Condition: Organoids · Breast Cancer · Neoadjuvant Chemotherapy · Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Breast cancer is the most common malignancy in women worldwide. Patients with breast cancer are often diagnosed at later stages and have a strong desire for breast conservation, necessitating neoadjuvant chemotherapy. Tumors of different molecular subtypes and individual variations among patients lead to significant differences in treatment efficacy. Precise assessment of patients' responses to treatment regimens is imperative in advancing prognosis of breast cancer. In this study, 58 patients diagnosed with breast cancer and scheduled for neoadjuvant therapy will be recruited. Patient-derived organoids from their tumor biopsies will be utilized to evaluate the sensitivity of chemotherapy regimen. These drugs primarily include Doxorubicin, Carboplatin, Cyclophosphamide, Paclitaxel, as well as targeted therapies such as Herceptin and Pertuzumab.
This description comes directly from the study's public registry record.
ZHIGANG CHEN · +8657189713716 · chenzg@zju.edu.cn
Jian Huang · +8657189713716 · drhuangjian@zju.edu.cn
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| 2 nd Affiliated Hospital, School of Medicine, Zhejiang University, China | Hangzhou, Zhejiang, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06155305