← Eichor
Study identifier: NCT06153966 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717

Condition: Prion Disease  ·  Sponsor: Ionis Pharmaceuticals, Inc.

PhasePhase 1/Phase 2
Planned participants76
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of intrathecal (IT) delivery of ION717.

This description comes directly from the study's public registry record.

Talk to the study team

Ionis Pharmaceuticals, Inc.  ·  (844) 892-5665  ·  PrionDisease@clinicaltrialmedia.com

Always discuss trial participation with your own doctor first.

Locations (13)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
NYU Langone HealthNew York, New York, United StatesRecruiting
University Hospitals Cleveland Medical CenterCleveland, Ohio, United StatesRecruiting
Royal Melbourne HospitalParkville, AustraliaRecruiting
McGill University Health CentreMontreal, Quebec, CanadaActive Not Recruiting
Hôpital Universitaire Pitié SalpêtrièreParis, FranceRecruiting
University Medical Center GöttingenGöttingen, GermanyRecruiting
Tel Aviv Sourasky Medical CenterTel Aviv, IsraelRecruiting
Fondazione I.R.C.C.S. Istituto Neurologico Carlo BestaMilan, ItalyRecruiting
Mihara Memorial HospitalGunma, Isesaki-shi, JapanActive Not Recruiting
National Center of Neurology and PsychiatryTokyo, Kodaira-shi, JapanRecruiting
Neuromuscular Center Yoshimizu HospitalYamaguchi, Shimonoseki-shi, JapanRecruiting

+ 1 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT06153966