Condition: Asthma · COPD · Sponsor: University of California, San Francisco
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic Obstructive Pulmonary Disease (COPD). The main questions it aims to answer are: * Does delivery of aerosolized NAC with positive inspiratory pressure have a greater effect on mucus plug burden in the lungs than delivery of NAC without positive pressure. * Does delivery of aerosolized NAC with positive inspiratory pressure have a greater effect on lung function than delivery of NAC without positive pressure. Participants will be assigned (in a single blind design) to the NAC via jet nebulizer group or the NAC via AeroEclipse-VersaPAP nebulizer group. Participants will each complete 5 treatment visits over the course of 30 days. Each treatment visit will consist of two treatments of a 10% NAC (3 mL) and 2.5 mg albuterol (0.5mL) inhalation solution separated by 4 hours, via the nebulization method specific to their group.
This description comes directly from the study's public registry record.
Jade Vi, BS · 415-476-1783 · jade.vi@ucsf.edu
John Fahy, MD, MS · 415-476-9940 · john.fahy@ucsf.edu
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| UCSF Airway Clinical Research Center | San Francisco, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06152653