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Study identifier: NCT06146764 Synced from ClinicalTrials.gov · July 28, 2026
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CEUS Improves the Diagnostic Performance of SRSS of Thyroid Carcinoma

Condition: Thyroid Nodule · Thyroid Carcinoma  ·  Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

PhaseN/A
Planned participants800
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Contrast-enhanced ultrasound (CEUS) can sensitively show the blood perfusion characteristics of thyroid nodules, which is a useful supplement to gray-scale ultrasound. However, there is no standard combined diagnostic method of gray-scale ultrasound and CEUS. Therefore, the aim of this study was to compare the diagnostic performance of the integrated scoring method and the up-and-down scoring method. This study was a multicenter retrospective clinical study and followed the Standards for Reporting of Diagnostic Accuracy Studies (version 2015). Inclusion criteria: 1) participants with at least one thyroid nodule larger than 5 mm confirmed by conventional ultrasound; 2) participants underwent gray-scale ultrasound, contrast-enhanced ultrasound and fine needle aspiration biopsy of the thyroid nodule successively; 3) participants have a final diagnosis of benign or malignant. Exclusion criteria included: 1) participants with cytologic findings of Bethesda I, III, or IV without definitive benign or malignant pathologic findings; 2) participants with a history of thyroid fine needle aspiration, ablation or surgery; 3) participants with low quality ultrasound images (e.g., severe artifacts or low image resolution). According to the American College of Radiology Thyroid Imaging Reporting and Data System, only one thyroid nodule with the highest point was included in each participant. A total of 600 participants from January 2018 to December 2022 were consecutively included in Sun Yat…

This description comes directly from the study's public registry record.

Talk to the study team

Jingliang Ruan, Ph.D.  ·  +8613694202230  ·  ruanjl3@mail.sysu.edu.cn

Xiaming Ye, Master  ·  +8613660362226  ·  Yexm7@mail.sysu.edu.cn

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Locations (1)

Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06146764