Condition: Glioblastoma · Glioblastoma Multiforme · Glioblastoma, IDH-wildtype · Sponsor: Jasper Gerritsen
There is no consensus on the optimal treatment of patients with high-grade glioma, especially when patients have limited functioning performance at presentation (KPS ≤70). Therefore, there are varied practice patterns around pursuing biopsy, resection, or palliation (best supportive care). This study aims to characterize the impact of palliative care versus biopsy versus resection on survival and quality of life in these patients. Also, it will aim to determine if there is a subset of patients that benefit the most from resection or biopsy, for which outcome, and how they could be identified preoperatively. This study is an international, multicenter, prospective, 3-arm cohort study of observational nature. Consecutive HGG patients will be treated with palliative care, biopsy, or resection at a 1:3:3 ratio. Primary endpoints are: 1) overall survival, and 2) quality of life at 6 weeks, 3 months and 6 months after initial presentation based on the EQ-5D, EORTC QLQ C30 and EORTC BN 20 questionnaires. Total duration of the study is 5 years. Patient inclusion is 4 years, follow-up is 1 year.
This description comes directly from the study's public registry record.
Jasper Gerritsen, MD PhD · 31107036130 · j.gerritsen@erasmusmc.nl
Arnaud Vincent, MD PhD · 31107034211 · a.vincent@erasmusmc.nl
Always discuss trial participation with your own doctor first.
| University of California, San Francisco | San Francisco, California, United States | Recruiting |
| Massachusetts General Hospital | Boston, Massachusetts, United States | Recruiting |
| University Hospital Leuven | Leuven, Belgium | Recruiting |
| Technical University Munich | Munich, Bavaria, Germany | Not Yet Recruiting |
| University Hospital Heidelberg | Heidelberg, Germany | Recruiting |
| Erasmus Medical Center | Rotterdam, South Holland, Netherlands | Recruiting |
| Haaglanden Medical Centre | The Hague, South Holland, Netherlands | Recruiting |
| Inselspital Universitätsspital Bern | Bern, Switzerland | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06146738