Condition: Age Problem · Dialysis; Complications · Frailty · Sponsor: Soonchunhyang University Hospital
As Korea is becoming a super-aged society, the number of elderly patients with end-stage kidney disease (ESKD) is expected to increase rapidly. Therefore, the burden on Korean society will also increase. Thrice-weekly hemodialysis is standard for renal replacement therapy. However, this regimen has not been validated for elderly ESKD patients with residual renal function. Elderly patients can have multiple comorbidities such as hypertension, diabetes, cardiovascular disease, and impaired physical activity. Frequent hemodialysis could provoke falls, hypotension, and cognitive impairment. Previous reports have suggested the potential benefit of twice-weekly hemodialysis with incremental increases in frequency when residual renal function decreases. In addition, twice-weekly hemodialysis decreases hospitalization rates in frail patients. Therefore, the investigators hypothesized initiating renal replacement therapy with twice-weekly hemodialysis decreases the hopsitalizatoin rates compared with conventional thrice-weekly hemodialysis in elderly ESRD patients with residual renal function. This study is a pragmatic randomized clinical trial, multicenter study. Study subjects are incident ESRD patients (\>= 60 years old, n=428) with residual urine volume ( \> 500 mL/day) and follow up up to 2 years. Twice-weekly hemodialysis could be incremented according to clinical situations such as volume overload, hyperkalemia and uremic symptom. Primary outcome of this study is hospitalizat…
This description comes directly from the study's public registry record.
Soon Hyo Kwon, MD · +8227099177 · ksoonhyo@schmc.ac.kr
Sook Kim · +8227099177 · himoomin@naver.com
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| Soonchunhyang University Hospital Bucheon | Bucheon-si, South Korea | Recruiting |
| Hallym University Medical Center- Chuncheon | Chuncheon, South Korea | Completed |
| Soonchunhyang University Seoul Hospital | Seoul, South Korea | Active Not Recruiting |
| Kangbuk Samsung Medical Center | Seoul, South Korea | Completed |
| Koera University Guro Hospital | Seoul, South Korea | Completed |
| The Catholic University of Korea, Yeouido St. Mary's Hospital | Seoul, South Korea | Completed |
| Yonsei University, Wonju Severance Christian Hospital | Wŏnju, South Korea | Completed |
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Source record: clinicaltrials.gov/study/NCT06141798