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Study identifier: NCT06139107 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

RADIANT: Pre-op Radiation With Abemaciclib and Letrozole

Condition: Breast Cancer  ·  Sponsor: Mridula George, MD

PhasePhase 1
Planned participants15
Who can joinFemale, 60 Years to no upper limit
Healthy volunteersNo

About this study

This phase 1b study investigates the safety and feasibility of combining pre-operative radiation therapy with Cyclin-Dependent Kinase 4 (CDK4/6) inhibitors in participants with hormone receptor positive/HER2 negative (HR+/HER2-) breast cancer. The study aims to assess the benefits of concurrent use of these treatments in a specific participant population, focusing on their safety and tolerability. The hypothesis is that the combination therapy will be well-tolerated, providing valuable insights into its effectiveness for future clinical applications.

This description comes directly from the study's public registry record.

Talk to the study team

Mridula A George, MD  ·  732-235-9081  ·  mridula@cinj.rutgers.edu

Mridula A George, MD  ·  Mridula  ·  mridula@cinj.rutgers.edu

Always discuss trial participation with your own doctor first.

Locations (4)

RWJBarnabas Health Clara Maas Medical CenterBelleville, New Jersey, United StatesRecruiting
Cooperman Barnabas Medical CenterLivingston, New Jersey, United StatesRecruiting
Rutgers Cancer Institute of New JerseyNew Brunswick, New Jersey, United StatesRecruiting
RWJBarnabas Health - Robert Wood Johnson University Hospital SomersetSomerville, New Jersey, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06139107