Condition: GastroEsophageal Cancer · Incurable Disease · Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
The survival of patients with incurable gastroesophageal cancer can extend over a year with anticancer therapy. However, the number of patients with deteriorating quality of life in this patient group steadily decreases over time during the treatment. Potentially reversible causes related to deterioration of quality of life are diminished muscle mass, physical capacity and nutritional status. Therefore, interventions that can target these in order to maintain or improve quality of life are urgently needed. However, it is yet unknown whether improvement of physical capacity and nutritional status improves quality of life in patients with incurable gastroesophageal adenocarcinoma after failure of first-line treatment. Since these patients are in a precarious situation, the benefits and harms of a combined exercise and nutritional intervention should be carefully evaluated.Therefore this study investigates the effect of a combined exercise and nutrition intervention compared to usual care on quality of life in incurable GAC patients after progression upon first-line treatment. A total of 196 patients with metastasized gastroesophageal cancer will be recruited and randomly allocated 1:1 to standard care or standard care plus a combined exercise and nutritional intervention.
This description comes directly from the study's public registry record.
Aniek Bonhof, Msc · +31627437310 · A.Bonhof-3@umcutrecht.nl
Always discuss trial participation with your own doctor first.
| Amsterdam UMC | Amsterdam, North Holland, Netherlands | Recruiting |
| UMC Utrecht | Utrecht, Utrecht, Netherlands | Recruiting |
| Jeroen Bosch Hospital | 's-Hertogenbosch, Netherlands | Active Not Recruiting |
| Flevoziekenhuis | Almere Stad, Netherlands | Recruiting |
| Meander Medical Center | Amersfoort, Netherlands | Not Yet Recruiting |
| Reinier de Graaf | Delft, Netherlands | Recruiting |
| Catharina Ziekenhuis | Eindhoven, Netherlands | Recruiting |
| Beatrix Hospital | Gorinchem, Netherlands | Recruiting |
| Spaarne Gasthuis | Hoofddorp, Netherlands | Recruiting |
| Frisius Medical Center | Leeuwarden, Netherlands | Recruiting |
| Leiden Universitair Medisch Centrum | Leiden, Netherlands | Recruiting |
| Sint Antonius Hospital | Nieuwegein, Netherlands | Not Yet Recruiting |
+ 10 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06138223