Condition: Poliomyelitis · Sponsor: PATH
The main objectives of this study are to : * evaluate the safety and tolerability of trivalent novel oral poliovirus vaccines (tnOPV) in healthy adults, young children, and neonates, relative to those receiving control vaccines; * evaluate the safety and tolerability of combined novel oral poliovirus vaccine type 1 (nOPV1) + novel oral poliovirus vaccine type 2 (nOPV2) in neonates, relative to those receiving the bivalent (types 1 and 3) oral poliovirus vaccine (bOPV) control. * compare type-specific cumulative seroconversion rates of poliovirus neutralizing antibody (NAb) titers, among all tnOPV dose combinations, following 4 vaccinations in healthy neonates; * evaluate the type-specific cumulative seroconversion rate of poliovirus NAb titers among healthy neonates following 4 doses of combined nOPV1+nOPV2.
This description comes directly from the study's public registry record.
Nicole Grunenberg, MD · 206-285-3500 · ngrunenberg@path.org
Always discuss trial participation with your own doctor first.
| International Centre for Diarrhoeal Disease Research | Dhaka, Bangladesh | Not Yet Recruiting |
| International Centre for Diarrhoeal Disease Research | Dhaka, Bangladesh | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06137664