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Study identifier: NCT06136884 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases

Condition: Solid Tumor Malignancies · Brain Metastases From Solid Tumors  ·  Sponsor: A2A Pharmaceuticals Inc.

PhasePhase 1
Planned participants86
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to assess the safety, tolerability and efficacy of the study drug AO-252 and identify the best dose for use in future studies.

This description comes directly from the study's public registry record.

Talk to the study team

Robbin Frnka, Chief ClinOps Officer  ·  2142055746  ·  rfrnka@coiledtx.com

Always discuss trial participation with your own doctor first.

Locations (6)

Karmanos Cancer InstituteDetroit, Michigan, United StatesRecruiting
Oklahoma UniveristyOklahoma City, Oklahoma, United StatesRecruiting
Hollings Cancer Center - MUSCCharleston, South Carolina, United StatesRecruiting
Mary Crowley Cancer ResearchDallas, Texas, United StatesRecruiting
The University of Texas M.D. Anderson Cancer CenterHouston, Texas, United StatesRecruiting
Next Oncology -VirginiaFairfax, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06136884