Condition: Metastatic Castration-resistant Prostate Cancer (mCRPC) · Prostatic Neoplasms · Sponsor: Merck Sharp & Dohme LLC
The purpose of this study is to assess the efficacy and safety of opevesostat plus daily corticosteroids compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) previously treated with one next-generation hormonal agent (NHA). The primary study hypothesis is that opevesostat is superior to alternative abiraterone acetate or enzalutamide with respect to radiographic progression free survival (rPFS) per Prostate Cancer Working Group (PCWG) Modified Response Evaluation Criteria in Solid Tumors (RECIST 1.1), as assessed by Blinded Independent Central Review (BICR), in androgen receptor ligand binding domain (AR LBD) mutation positive and negative participants.
This description comes directly from the study's public registry record.
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| The University of Arizona Cancer Center - North Campus ( Site 0073) | Tucson, Arizona, United States | Recruiting |
| UCLA Hematology/Oncology - Santa Monica ( Site 0044) | Los Angeles, California, United States | Recruiting |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040) | Orange, California, United States | Recruiting |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center (0120) | Orange, California, United States | Recruiting |
| Stanford Cancer Center ( Site 0036) | Palo Alto, California, United States | Recruiting |
| Emad Ibrahim,MD,INC. ( Site 0012) | Redlands, California, United States | Completed |
| Kaiser Permanente Riverside Medical Center ( Site 0099) | Riverside, California, United States | Recruiting |
| University of California Davis (UC Davis) Comprehensive Cancer Center ( Site 0114) | Sacramento, California, United States | Recruiting |
| San Francisco VA Health Care System ( Site 0093) | San Francisco, California, United States | Recruiting |
| Kaiser Permanente-Kaiser Permanente, Vallejo Medical Center, Adult Oncology ( Site 0101) | Vallejo, California, United States | Recruiting |
| University of Colorado Anschutz Medical Campus ( Site 0046) | Aurora, Colorado, United States | Recruiting |
| UCHealth Highlands Ranch Hospital ( Site 0111) | Highlands Ranch, Colorado, United States | Recruiting |
+ 317 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06136650