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Study identifier: NCT06136546 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

Condition: Depressive Disorder, Major · Inflammation  ·  Sponsor: Massachusetts General Hospital

PhasePhase 2
Planned participants100
Who can joinAll sexes, 25 Years to 50 Years
Healthy volunteersNo

About this study

This study is a mechanistic randomized controlled trial that investigates whether inhibition of tumor necrosis factor signaling via intravenous infusion of infliximab improves psychomotor speed and executive functioning in depressed individuals who exhibit an inflammatory phenotype.

This description comes directly from the study's public registry record.

Talk to the study team

Naoise Mac Giollabhui, PhD  ·  6177241000  ·  nmacgiollabhui@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06136546