Condition: Pneumonia, Viral · Ventilator Associated Pneumonia · Community-acquired Pneumonia · Sponsor: Jena University Hospital
Almost 90 out of 100 people carry herpes simplex viruses (HSV). Once a person has been infected with the herpes viruses, he or she can't get rid of them for the rest of her/his life. For the most part, the viruses are in a dormant state. Only when the immune system is weakened, for example in the case of a serious illness or stress, are the viruses reactivated. They then mainly cause cold sores, which are harmless for healthy people and usually heal without therapy. However, especially in people with a weakened immune system, HSV can also cause serious infections, such as meningitis. In almost every second mechanically ventilated patient in intensive care who has pneumonia, HSV can be detected in the respiratory tract. This is caused by reactivation of the viruses as a result of the severe underlying disease and stress during intensive care therapy. Whether treatment of the herpes viruses (e.g. with acyclovir) is necessary in this situation and helps the patients to cure has not been clarified, especially as acyclovir can also cause side effects such as a deterioration in kidney function. Currently, the physicians decide to treat the herpes viruses in about half of the patients. Several studies have shown that patients for whom the physician decided to treat the viruses survived more often. However, all of these studies looked at the course of the disease only retrospectively and thus are subject to many biases (including physician selection of who receives treatment, missing…
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| Universitätsklinikum Freiburg | Freiburg im Breisgau, Baden-Wurttemberg, Germany | Recruiting |
| Universitätsklinikum Heidelberg | Heidelberg, Baden-Wurttemberg, Germany | Recruiting |
| Universitätsklinikum Heidelberg | Heidelberg, Baden-Wurttemberg, Germany | Recruiting |
| Universitätsklinikum Tübingen | Tübingen, Baden-Wurttemberg, Germany | Recruiting |
| Universitätsklinikum Augsburg | Augsburg, Bavaria, Germany | Recruiting |
| Klinikum der Ludwig-Maximilian-Universität München | München, Bavaria, Germany | Recruiting |
| Klinikum rechts der Isar | München, Bavaria, Germany | Recruiting |
| Klinikum rechts der Isar | München, Bavaria, Germany | Recruiting |
| Klinikum Nürnberg, Campus Nord | Nuremberg, Bavaria, Germany | Recruiting |
| Klinikum Nürnberg, Campus Süd | Nuremberg, Bavaria, Germany | Recruiting |
| Universitätsklinikum Regensburg | Regensburg, Bavaria, Germany | Recruiting |
| RoMed Klinikum Rosenheim | Rosenheim, Bavaria, Germany | Recruiting |
+ 16 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06134492