Condition: Bipolar Disorder I or II · Sponsor: Leiden University Medical Center
The main goal of this study is to determine if brain lithium-concentrations predict clinical lithium treatment-response. Secondary, to study correlations between intracerebral distribution-patterns of lithium with clinical treatment outcome. Brain lithium concentrations will be measured using ultra-high field (7 Tesla) lithium magnetic resonance (MR) imaging, which has recently been introduced. Determining lithium-concentrations in the brain has been difficult so far due to lithium's relatively low concentration (compared to protons, which are targeted in conventional MRI). 7T lithium MR imaging has the potential to produce much more detailed MR images compared with previous studies, for the first time. The BLISS study is expected to yield new insights, helping to better understand why clinical lithium response varies between individuals.
This description comes directly from the study's public registry record.
E Boere · +31(0)715263785 · bliss@lumc.nl
Onderzoekscentrum Psychiatrie, OZC · bliss@lumc.nl
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| Leiden University Medical Center | Leiden, South Holland, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06134349