Condition: Colorectal Neoplasms · Carcinoma, Non-Small-Cell Lung · Stomach Neoplasms · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or has spread to other parts of the body, it is called unresectable. These types of cancer are harder to treat. Participants in this study must have cancer that has come back or did not get better with treatment. Participants must have a solid tumor cancer that can't be treated with standard of care drugs. This clinical trial uses an experimental drug called PF-08046050. PF-08046050 is a type of antibody-drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. They may also stick to some normal cells. This study will test the safety of PF-08046050 in participants with solid tumors that are hard to treat or have spread throughout the body. This study has 5 different study parts. Part A and Part B of the study will find out how much PF-08046050 should be given to participants. Part C will use the information from Parts A and B to see if PF-08046050 is safe and if it works to treat certain solid tumor cancers. Part D and E of the study, together with information from Parts A and B, will find out how much PF-08046050 should be given in combination with other anti-…
This description comes directly from the study's public registry record.
Pfizer CT.gov Call Center · 1-800-718-1021 · ClinicalTrials.gov_Inquiries@pfizer.com
Always discuss trial participation with your own doctor first.
| Mayo Clinic Hospital | Phoenix, Arizona, United States | Recruiting |
| Mayo Clinic | Scottsdale, Arizona, United States | Recruiting |
| City of Hope (City of Hope National Medical Center, City of Hope Medical Center) | Duarte, California, United States | Recruiting |
| IP Address: City of Hope Investigational Drug Services(IDS) | Duarte, California, United States | Recruiting |
| University of Colorado Hospital - Anschutz Cancer Pavilion (ACP) | Aurora, Colorado, United States | Recruiting |
| University of Colorado Hospital | Aurora, Colorado, United States | Recruiting |
| Florida Cancer Specialists | Orlando, Florida, United States | Recruiting |
| Sarah Cannon Research Institute at Florida Cancer Specialists | Orlando, Florida, United States | Recruiting |
| Sidney Kimmel Comprehensive Cancer at Johns Hopkins | Baltimore, Maryland, United States | Recruiting |
| Beth Israel Deaconess Medical Center | Boston, Massachusetts, United States | Recruiting |
| START Midwest | Grand Rapids, Michigan, United States | Recruiting |
| Mayo Clinic Cancer Center | Rochester, Minnesota, United States | Recruiting |
+ 36 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06131840