Condition: Recurrent High Grade Glioma · Sponsor: Duke University
This is a Phase 1 open label study designed to assess the safety and tolerability of the oncolytic herpes simplex virus 1 (oHSV1) study drug, MVR-C5252, administered intratumorally by convection-enhanced delivery (CED) in patients with recurrent high-grade glioma. Once the safety and maximum tolerated dose (MTD) is established in the dose escalation portion of the trial, a dose expansion cohort at the recommended phase 2 dose (RP2D) in patients with isocitrate dehydrogenase (IDH) wildtype recurrent glioblastoma (GBM) will evaluate preliminary efficacy of the study drug.
This description comes directly from the study's public registry record.
Mustafa Khasraw, MD · 919 684 5301 · mustafa.khasraw@duke.edu
Stieve Threatt · 919-684-5301 · dukebrain1@duke.edu
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| Memorial Sloan Kettering | New York, New York, United States | Recruiting |
| Duke University | Durham, North Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06126744