Condition: Liver Dysfunction · Liver Metastasis Colon Cancer · Liver Regeneration · Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
The primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy. The main questions it aims to answer are: 1. Does high-dose insulin therapy improve liver function in the pre-operative setting? 2. What is the effect of high-dose insulin therapy on liver function and liver regeneration after a liver venous deprivation (LVD) procedure? 3. What is the relationship between volume hypertrophy and function in the regenerating liver? Participants will receive a 6-hour infusion of insulin and dextrose to maintain a hyperinsulinemic-normoglycemic state in the weeks prior to planned liver surgery to assess its effect on liver function measured by 99m-Tc-Mebrofenin hepatobiliary scintigraphy.
This description comes directly from the study's public registry record.
Jennifer Kalil, MD · 514-934-1934 · jennifer.kalil@mail.mcgill.ca
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| McGill Univeristy Health Centre | Montreal, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06126419