Condition: Malignant Female Reproductive System Neoplasm · Malignant Solid Neoplasm · Recurrent Malignant Female Reproductive System Neoplasm · Sponsor: National Cancer Institute (NCI)
This phase II ComboMATCH treatment trial compares the effect of neratinib to the combination of neratinib and palbociclib in treating patients with HER2 positive solid tumors. Neratinib and palbociclib are in a class of medications called kinase inhibitors. They work by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of tumor cells. Giving neratinib and palbociclib in combination may shrink or stabilize cancers that over-express a specific biomarker called HER2.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | Recruiting |
| University of South Alabama Mitchell Cancer Institute | Mobile, Alabama, United States | Recruiting |
| Alaska Women's Cancer Care | Anchorage, Alaska, United States | Recruiting |
| UC San Diego Health System - Encinitas | Encinitas, California, United States | Suspended |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Suspended |
| The Angeles Clinic and Research Institute - West Los Angeles Office | Los Angeles, California, United States | Recruiting |
| Cedars-Sinai Medical Center | Los Angeles, California, United States | Recruiting |
| UC San Diego Medical Center - Hillcrest | San Diego, California, United States | Suspended |
| UM Sylvester Comprehensive Cancer Center at Aventura | Aventura, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Springs | Coral Springs, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, United States | Recruiting |
+ 176 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06126276