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Study identifier: NCT06126224 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)

Condition: Psychosis Associated With Alzheimer's Disease  ·  Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

PhasePhase 3
Planned participants500
Who can joinAll sexes, 55 Years to 90 Years
Healthy volunteersNo

About this study

This is a Phase 3, randomized, double-blind, placebo-controlled, parallel group study to evaluate the safety and efficacy of KarXT in male and female subjects who are aged 55 to 90 years and have mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD. The primary objective of the study is to evaluate the efficacy of KarXT compared with placebo in the treatment of subjects with psychosis associated with AD as measured by the Neuropsychiatric Inventory-Clinician (NPI-C): Hallucinations and Delusions (H+D) score.

This description comes directly from the study's public registry record.

Talk to the study team

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com  ·  855-907-3286  ·  Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

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Locations (154)

Local Institution - 1116Chandler, Arizona, United StatesActive Not Recruiting
Local Institution - 1044Phoenix, Arizona, United StatesActive Not Recruiting
Local Institution - 1104Anaheim, California, United StatesActive Not Recruiting
Local Institution - 1119Canoga Park, California, United StatesActive Not Recruiting
Local Institution - 1151Encino, California, United StatesActive Not Recruiting
Local Institution - 1142Lancaster, California, United StatesActive Not Recruiting
Local Institution - 1117Los Alamitos, California, United StatesActive Not Recruiting
Local Institution - 1103Sherman Oaks, California, United StatesActive Not Recruiting
Local Institution - 1007Walnut Creek, California, United StatesActive Not Recruiting
Local Institution - 1160Apopka, Florida, United StatesWithdrawn
Local Institution - 1156Clermont, Florida, United StatesActive Not Recruiting
Local Institution - 1138Cutler Bay, Florida, United StatesActive Not Recruiting

+ 142 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06126224