Condition: Urothelial Carcinoma of the Renal Pelvis and Ureter · Transitional Cell Cancer of the Renal Pelvis and Ureter · Sponsor: University of British Columbia
The goal of this prospective clinical trial is to investigate the safety and efficacy of ST-02 (mucoadhesive gemcitabine suspension for pyelocaliceal instillation) to treat Upper Tract Urothelial Carcinoma (UTUC) in participants who have a low-grade tumor. The main questions this study aims to answer are: 1. Can ST-02 effectively eradicate UTUC by 3 months? 2. Is ST-02 safe for patients with UTUC? Participants in this study will receive ST-02, a new formulation with gemcitabine once weekly for six weeks. Gemcitabine is known to be an effective drug in treating urothelial carcinoma. This new formulation will be instilled directly into the upper urinary tract (renal pelvis) and will allow the chemotherapeutic to work locally for an extended period of time. The administration process will be retrograde (via a small catheter inserted up into the kidney, under anesthesia) or antegrade (via a nephrostomy, in the clinic) once weekly for six weeks. Safety and efficacy will be monitored for up to a year after the initial response assessment.
This description comes directly from the study's public registry record.
Dasa Durkotova · 236 869 3437 · ddurkotova@prostatecentre.com
Always discuss trial participation with your own doctor first.
| Vancouver Prostate Centre | Vancouver, British Columbia, Canada | Recruiting |
| Men's Health Clinic | Winnipeg, Manitoba, Canada | Recruiting |
| Centre of Applied Urology Research, Nova Scotia Health Authority | Halifax, Nova Scotia, Canada | Recruiting |
| UHN - Princess Margaret Cancer Centre | Toronto, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06124976