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Study identifier: NCT06121505 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase II Trial: Low-Dose Radiation + SBRT + Sintilimab + Chemotherapy vs. Sintilimab + Chemotherapy in Locally Advanced or Metastatic Squamous Cell Lung Cancer

Condition: Lung Squamous Cell Carcinoma  ·  Sponsor: Sichuan University

PhasePhase 2
Planned participants114
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a randomized, controlled, open-label, multicenter phase II clinical trial comparing the efficacy and safety of low-dose radiation therapy and stereotactic body radiation therapy combined with PD-1 inhibitor (sintilimab) and standard platinum-based doublet chemotherapy versus PD-1 inhibitor (sintilimab) combined with standard platinum-based doublet chemotherapy as first-line treatment in patients with locally advanced or metastatic squamous cell lung cancer. There will be 57 subjects in the experimental group and 57 subjects in the control group, with a total of 114 subjects.

This description comes directly from the study's public registry record.

Talk to the study team

Jianxin Xue, MD  ·  +86 189 8225 1798  ·  killercell@163.com

You Lu, MD  ·  +86 189 8060 1763  ·  radyoulu@hotmail.com

Always discuss trial participation with your own doctor first.

Locations (6)

The Second Affiliated Hospital of Chongqing Medical UniversityChongqing, Chongqing Municipality, ChinaRecruiting
Guizhou Provincial People's HospitalGuiyang, Guizhou, ChinaRecruiting
Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, Hunan, ChinaRecruiting
Sichuan Cancer HospitalChengdu, Sichuan, ChinaRecruiting
West China Hospital of Sichuan UniversityChengdu, Sichuan, ChinaRecruiting
Affiliated Hospital of North Sichuan Medical CollegeNanchong, Sichuan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06121505