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Study identifier: NCT06119581 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Condition: Carcinoma, Non-Small-Cell Lung · Neoplasm Metastasis  ·  Sponsor: Eli Lilly and Company

PhasePhase 3
Planned participants1264
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (419)

Clearview Cancer InstituteHuntsville, Alabama, United StatesRecruiting
Banner MD Anderson Cancer CenterGilbert, Arizona, United StatesRecruiting
Banner University Medical Center PhoenixPhoenix, Arizona, United StatesRecruiting
The University of Arizona Cancer Center - North CampusTucson, Arizona, United StatesRecruiting
Highlands Oncology GroupSpringdale, Arkansas, United StatesRecruiting
Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterTorrance, California, United StatesCompleted
BASS Cancer CenterWalnut Creek, California, United StatesRecruiting
USO - Rocky Mountain Cancer CentersLone Tree, Colorado, United StatesRecruiting
Yale University School of MedicineNew Haven, Connecticut, United StatesRecruiting
Sibley Memorial HospitalWashington D.C., District of Columbia, United StatesRecruiting
Millennium Oncology Research ClinicHollywood, Florida, United StatesRecruiting

+ 407 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06119581