Condition: Pulmonary Tuberculosis · Sponsor: University College, London
The UNITE4TB consortium is a group of universities and pharmaceutical companies funded by the European Union. This consortium are carrying out a trial to find better and faster ways to treat tuberculosis (TB). The standard treatment for TB takes 24 weeks and uses four drugs. The consortium want to find new treatments that are faster but just as safe and effective. In the trial, two new drugs will be used, BTZ-043 and GSK3036656, along with the drugs that are already used to treat TB in a variety of combinations (11 different combinations initially). These new drugs have worked well in tests with animals and have reduced the amount of TB bacteria in people's sputum/phlegm when used alone for two weeks. These new drugs will be used in combination with other TB drugs for a longer time (up to 16 weeks) in people with TB. The UNITE4TB consortium want to see if they work well and are safe. This trial will take place at sites across the world and will involve people with TB of the lungs that would usually respond well to the standard treatment. But the new treatments being tested might also work for people with drug resistant TB, that's harder to treat. The trial has two parts. In the first part, different combinations of drugs will be tried on up to 700 people for 16 weeks. These combinations will be compared to the standard 24-week treatment to see which ones work the best and are safe. In the second part, the best combinations from the first part will be taken to try to find …
This description comes directly from the study's public registry record.
Susie Slater · 20 7670 4789 · mrcctu.paradigm4tb@ucl.ac.uk
Karen Sanders · 2076704826 · karen.sanders@ucl.ac.uk
Always discuss trial participation with your own doctor first.
| PMSI Institute of Pneumology "Chiril Draganiuc" | Chisinau, Moldova | Active Not Recruiting |
| TASK Brooklyn | Cape Town, South Africa | Recruiting |
| University of Cape Town Lung Institute | Cape Town, South Africa | Recruiting |
| TASK Eden | George, South Africa | Recruiting |
| NIMR Mbeya | Mbeya, Tanzania | Recruiting |
| Kibong'oto Infectious Diseases Hospital | Moshi, Tanzania | Recruiting |
| NIMR Mwanza | Mwanza, Tanzania | Recruiting |
| Joint Clinical Research Centre | Kampala, Uganda | Recruiting |
| Makerere University Lung Institute | Kampala, Uganda | Recruiting |
| National Lung Hospital | Hanoi, Vietnam | Active Not Recruiting |
| Pnth/Oucru | Ho Chi Minh City, Vietnam | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT06114628