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Study identifier: NCT06111313 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

The University of Miami Adapt (UAdapt) Trial

Condition: Prostate Cancer  ·  Sponsor: University of Miami

PhasePhase 2
Planned participants130
Who can joinMale, 35 Years to 85 Years
Healthy volunteersNo

About this study

The purpose of this prostate cancer research study is to investigate: 1. For early-stage patients, the use of a single session of high dose stereotactic body radiotherapy (SBRT) delivered to the tumor within the prostate, not to the entire prostate, as curative treatment of prostate cancer; 2. The addition of ultra short-term androgen supression (uSTAS) to a single session of high dose SBRT as a means of intensifying treatment while preserving quality of life and minimizing side effects; 3. The ability of a single session of high dose SBRT to activate your immune system to enhance eradication of prostate cancer; 4. For higher risk patients, the use of a single session of high dose SBRT to the tumor only followed by 25 sessions of radiotherapy targeting the whole prostate as a means to improve control of disease while preserving quality of life and minimizing side effects; 5. The relationship between diagnostic imaging studies and prostate biopsy results in assessing clinical outcomes; and 6. The relationship of pre- and post-treatment prostate biopsy results and imaging studies, such as MRI and PET/CT.

This description comes directly from the study's public registry record.

Talk to the study team

Benjamin Spieler, MD  ·  305-243-4229  ·  bxs737@med.miami.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of MiamiMiami, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06111313