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Study identifier: NCT06108076 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes

Condition: Type 2 Diabetes · Heart Failure, Reduced Ejection Fraction  ·  Sponsor: The University of Texas Health Science Center at San Antonio

PhaseEARLY_Phase 1
Planned participants10
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.

This description comes directly from the study's public registry record.

Talk to the study team

Carolina Solis-Herrera, MD  ·  210-567-4900  ·  solisherrera@uthscsa.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Texas Health Science Center at San AntonioSan Antonio, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06108076